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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL140153
Molecular formula	C15H22ClN3O
IUPAC name	6-amino-7-chloro-2-[2-(diethylamino)ethyl]-3,4-dihydroisoquinolin-1-one
Molecular weight	295.811
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.1
Synonyms	N/A
Inchi Key	DKSYICLASPUIME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22ClN3O/c1-3-18(4-2)7-8-19-6-5-11-9-14(17)13(16)10-12(11)15(19)20/h9-10H,3-8,17H2,1-2H3
PubChem CID	15681439
ChEMBL	CHEMBL140153
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	5.1 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL
pD2	5.2 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL

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