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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	phenylpropanolamine
Molecular formula	C9H13NO
IUPAC name	2-amino-1-phenylpropan-1-ol
Molecular weight	151.209
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	0.8
Synonyms	Norephedrine, (+) Phenylpropanolamine (mixed isomers) (1R, 2R)-2-Amino-1-phenyl-propan-1-ol 1-phenyl-2-aminopropanol 24136-EP2269989A1 24136-EP2301933A1 Benzenemethanol, .alpha.-(1-aminoethyl)-, [S-(R,R)]- CHEMBL136560 DLNKOYKMWOXYQA-UHFFFAOYSA-N IDI1_000795 Norpseudoephedrine, (+)- SCHEMBL98589 (1s, 2r)-(+)-norephedrine 2-Amino-1-phenyl-1-propanol 24136-EP2295406A1 24136-EP2311827A1 alpha-(1-aminoethyl)benzyl alcohol Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.S)-rel- Contac MCULE-9503580838 Ornade (+)2-Amino-1-phenyl-propan-1-ol (1S,2R)-(+)-Norephedrine 2-amino-1-phenylpropan-1-ol 24136-EP2298776A1 48115-38-4 Benzenemethanol, .alpha.-(1-aminoethyl)-, (R,S)-(.+/-.)- Benzenemethanol, alpha-(1-aminoethyl)- Demazin Norephedrine, (-) Pseudonorephedrine, (+) [cathine, (+)] (1R, 2S)-2-Amino-1-phenyl-propan-1-ol 14838-15-4 24136-EP2272825A2 24136-EP2305640A2 AC1L1IYB Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)- FT-0630600 KBio1_000795 NSC-120735 TAVIST-D (1S, 2R)-2-Amino-1-phenyl-propan-1-ol 2-Amino-1-phenyl-1-propanol # 24136-EP2295409A1 24136-EP2314590A1 BDBM50022722 Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.R)- CTK7J6381 NINDS_000795 (1 S,2R)-(+)-norephedrine 2-Amino-2-methyl-1-phenylethanol 24136-EP2298779A1 492A411 Benzenemethanol, .alpha.-(1-aminoethyl)-, [R-(R,S)]- beta-Hydroxy-alpha-methylphenethylamine DivK1c_000795 Norephedrine, (.+/-.)- Pseudonorephedrine, (-) [cathine, (-)] (1S, 2R )-(+)-norephedrine 2-Amino-1-hydroxy-1-phenylpropane 24136-EP2281815A1 24136-EP2308839A1 AKOS015891154 Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)-rel- CHEMBL61006 I01-9308 L001077 NSC120735 (1S, 2S)-2-Amino-1-phenyl-propan-1-ol 2-Amino-1-phenyl-propan-1-ol 24136-EP2298772A1 37577-28-9 Benzenemethanol, .alpha.-(1-aminoethyl)- Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.S)- D-(+)-Norephedrine [ Show all ]
Inchi Key	DLNKOYKMWOXYQA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3
PubChem CID	4786
ChEMBL	CHEMBL61006
IUPHAR	N/A
BindingDB	50022722
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	265.0 nM	PMID12954796	PDSP,BindingDB
Ki	597.0 nM	PMID12954796	PDSP,BindingDB
Ki	1547.0 nM	PMID12954796	PDSP,BindingDB
Ki	2804.0 nM	PMID12954796	PDSP,BindingDB

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