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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameDIDODECANOYLPHLOROGLUCINOL
Molecular formulaC30H50O5
IUPAC name1-(3-dodecanoyl-2,4,6-trihydroxyphenyl)dodecan-1-one
Molecular weight490.725
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP11.6
Synonyms1,1'-(2,4,6-Trihydroxy-1,3-phenylene)bis(dodecan-1-one)
ZINC44417494
CHEMBL470757
1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-1-dodecanone
MolPort-044-550-959
[ Show all ]
Inchi KeyAIKYCZDMJFKXLS-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H50O5/c1-3-5-7-9-11-13-15-17-19-21-24(31)28-26(33)23-27(34)29(30(28)35)25(32)22-20-18-16-14-12-10-8-6-4-2/h23,33-35H,3-22H2,1-2H3
PubChem CID9957245
ChEMBLCHEMBL470757
IUPHARN/A
BindingDB50256011
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity100.2 %PMID18993064ChEMBL
EC5070.0 nMPMID18993064BindingDB,ChEMBL
EC5075.86 nMPMID18993064ChEMBL
FC2.326 -PMID18993064ChEMBL

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