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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	CHEMBL377163
Molecular formula	C18H23N5O2S2
IUPAC name	1-[1-(4,5-dihydro-1,3-thiazol-2-yl)-2-methyl-5-oxo-3-propan-2-ylpyrazol-4-yl]-3-(4-methylsulfanylphenyl)urea
Molecular weight	405.535
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.9
Synonyms	BDBM50186944 1-(1-(4,5-dihydrothiazol-2-yl)-3-isopropyl-2-methyl-5-oxo-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea
Inchi Key	AILRBWXTHGHPIV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H23N5O2S2/c1-11(2)15-14(16(24)23(22(15)3)18-19-9-10-27-18)21-17(25)20-12-5-7-13(26-4)8-6-12/h5-8,11H,9-10H2,1-4H3,(H2,20,21,25)
PubChem CID	44413526
ChEMBL	CHEMBL377163
IUPHAR	N/A
BindingDB	50186944
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5130.0 nM	PMID16697190	BindingDB,ChEMBL

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