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GPCR

NameC-C chemokine receptor type 4
SpeciesHomo sapiens (Human)
GeneCCR4
SynonymK5-5
ChemR13
chemokine (C-C motif) receptor 4
CD194
CCR4
[ Show all ]
DiseaseAsthma
Atopic dermatitis
Autoimmune diabetes
Length360
Amino acid sequenceMNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
UniProtP51679
Protein Data BankN/A
GPCR-HGmod modelP51679
3D structure modelThis predicted structure model is from GPCR-EXP P51679.
BioLiPN/A
Therapeutic Target DatabaseT06955
ChEMBLCHEMBL2414
IUPHAR61
DrugBankN/A

Ligand

NameCHEMBL470960
Molecular formulaC27H35N5O2
IUPAC name6,7-dimethoxy-N-(2-phenylethyl)-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Molecular weight461.61
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP5.3
SynonymsN/A
Inchi KeyDLVFKSQCSGECLA-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H35N5O2/c1-33-24-18-22-23(19-25(24)34-2)29-27(30-26(22)28-13-10-20-8-4-3-5-9-20)32-16-11-21(12-17-32)31-14-6-7-15-31/h3-5,8-9,18-19,21H,6-7,10-17H2,1-2H3,(H,28,29,30)
PubChem CID44561558
ChEMBLCHEMBL470960
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition4.0 %PMID18539035ChEMBL
Inhibition7.0 %PMID18539035ChEMBL

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