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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameSCHEMBL94215
Molecular formulaC27H27N3O2
IUPAC name1-(7-methyl-1,2,3,5,6,11c-hexahydroindolizino[7,8-b]indol-9-yl)-4-phenylmethoxypyridin-2-one
Molecular weight425.532
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.6
SynonymsCHEMBL3675287
BDBM109799
US8618299, 17
Inchi KeyAIOLBXVVPXZRPR-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H27N3O2/c1-28-23-12-14-29-13-5-8-24(29)27(23)22-10-9-20(16-25(22)28)30-15-11-21(17-26(30)31)32-18-19-6-3-2-4-7-19/h2-4,6-7,9-11,15-17,24H,5,8,12-14,18H2,1H3
PubChem CID49869049
ChEMBLCHEMBL3675287
IUPHARN/A
BindingDB109799
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki12.0 nM, NoneBindingDB,ChEMBL

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