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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL350961
Molecular formulaC39H40ClN7O3S
IUPAC nameethyl 5-[(E)-[[3-[[9-(2-chlorophenyl)-3,7-dimethyl-17-thia-2,4,5,8,14-pentazatetracyclo[8.7.0.02,6.011,16]heptadeca-1(10),3,5,8,11(16)-pentaen-14-yl]methyl]phenyl]-pyridin-3-ylmethylidene]amino]oxypentanoate
Molecular weight722.305
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP6.8
Synonyms5-[[(Z)-alpha-(3-Pyridyl)-3-[1,4-dimethyl-6-(2-chlorophenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9-ylmethyl]benzylidene]aminooxy]valeric acid ethyl ester
BDBM50110452
5-[(3-[1,4-dimethyl-6-(2-chloro-phenyl)-7,8,9,10-tetrahydro-4H-pyrido[4'',3'':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-9-yl-methyl]-phenyl)-pyridin-3-yl-methyleneaminooxy]-pentanoic acid ethyl ester
Inchi KeyDNRNTTDVQRLAPY-AESNPLDJSA-N
Inchi IDInChI=1S/C39H40ClN7O3S/c1-4-49-34(48)16-7-8-20-50-45-36(29-13-10-18-41-22-29)28-12-9-11-27(21-28)23-46-19-17-31-33(24-46)51-39-35(31)37(30-14-5-6-15-32(30)40)42-25(2)38-44-43-26(3)47(38)39/h5-6,9-15,18,21-22,25H,4,7-8,16-17,19-20,23-24H2,1-3H3/b45-36+
PubChem CID44377911
ChEMBLCHEMBL350961
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
ED50<10.0 mg.kg-1PMID11858999ChEMBL
ED500.2 mg.kg-1PMID11858999ChEMBL

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