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GPCR

NameSubstance-K receptor
SpeciesCavia porcellus (Guinea pig)
GeneTACR2
SynonymNeurokinin A receptor
NK-2 receptor
NK-2R
SKR
Tachykinin receptor 2
DiseaseN/A for non-human GPCRs
Length402
Amino acid sequenceMGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
UniProtQ64077
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2647
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL172572
Molecular formulaC29H30Cl2N4O3
IUPAC name1-[2-[(5R)-5-(3,4-dichlorophenyl)-3-(pyridine-3-carbonyl)-1,3-oxazolidin-5-yl]ethyl]-4-phenylpiperidine-4-carboxamide
Molecular weight553.484
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.9
Synonyms1-[2-[(5R)-3-(3-Pyridinylcarbonyl)-5-(3,4-dichlorophenyl)-5alpha-oxazolidinyl]ethyl]-4-phenylpiperidine-4-carboxamide
Inchi KeyDOGIWFIADYEHER-LJAQVGFWSA-N
Inchi IDInChI=1S/C29H30Cl2N4O3/c30-24-9-8-23(17-25(24)31)29(19-35(20-38-29)26(36)21-5-4-13-33-18-21)12-16-34-14-10-28(11-15-34,27(32)37)22-6-2-1-3-7-22/h1-9,13,17-18H,10-12,14-16,19-20H2,(H2,32,37)/t29-/m0/s1
PubChem CID44382207
ChEMBLCHEMBL172572
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition48.0 %PMID10206553ChEMBL

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