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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL541756 |
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Molecular formula | C19H24ClN3O |
IUPAC name | 5-chloro-1-[(1R)-1-cyclopropylpropyl]-3-(2,4,5-trimethylanilino)pyrazin-2-one |
Molecular weight | 345.871 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | (R)-5-Chloro-1-(1-cyclopropylpropyl)-3-(2,4,5-trimethylphenylamino)pyrazin-2(1H)-one BDBM50293972 |
Inchi Key | AIVCJNWFJCLYGU-MRXNPFEDSA-N |
Inchi ID | InChI=1S/C19H24ClN3O/c1-5-16(14-6-7-14)23-10-17(20)22-18(19(23)24)21-15-9-12(3)11(2)8-13(15)4/h8-10,14,16H,5-7H2,1-4H3,(H,21,22)/t16-/m1/s1 |
PubChem CID | 44190336 |
ChEMBL | CHEMBL541756 |
IUPHAR | N/A |
BindingDB | 50293972 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 2.4 nM | PMID19552437 | BindingDB,ChEMBL |
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