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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A1
Species	Rattus norvegicus (Rat)
Gene	Adora1
Synonym	A1 receptor A1-AR A1R adenosine receptor A1 RDC7
Disease	N/A for non-human GPCRs
Length	326
Amino acid sequence	MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
UniProt	P25099
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL318
IUPHAR	18
DrugBank	N/A

Ligand

Name	CHEMBL431370
Molecular formula	C11H12N4
IUPAC name	3,5,8-trimethyl-1,6-dihydropyrazolo[4,3-f]indazole
Molecular weight	200.245
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.0
Synonyms	Benzo[1,2-c:5,4-c']dipyrazole, 1,7-dihydro-3,5,8-trimethyl- 115705-37-8 BDBM50022734 3,5,8-Trimethyl-1,7-dihydro-benzo[1,2-c;5,4-c'']dipyrazole
Inchi Key	AIWFKMLZLPPKGA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H12N4/c1-5-10-8(6(2)12-14-10)4-9-7(3)13-15-11(5)9/h4H,1-3H3,(H,12,14)(H,13,15)
PubChem CID	14185402
ChEMBL	CHEMBL431370
IUPHAR	N/A
BindingDB	50022734
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1200.0 nM	PMID3172141	BindingDB,ChEMBL

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