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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL206831
Molecular formulaC28H31F4N5O
IUPAC name1-[(1S,2R,5S)-5-(4-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(3-piperazin-1-ylpropyl)urea
Molecular weight529.584
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.3
SynonymsBDBM50184936
N-[trans-5-(4-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N''-[4-fluoro-3-(trifluoromethyl)phenyl)-N-[3-(1-piperazinyl)propyl]urea
Inchi KeyDQAUVQWGUDFZKV-DFZDUAMZSA-N
Inchi IDInChI=1S/C28H31F4N5O/c29-24-7-6-21(16-22(24)28(30,31)32)35-26(38)37(13-1-12-36-14-10-34-11-15-36)25-8-9-27(17-23(25)27)20-4-2-19(18-33)3-5-20/h2-7,16,23,25,34H,1,8-15,17H2,(H,35,38)/t23-,25-,27-/m1/s1
PubChem CID11533835
ChEMBLCHEMBL206831
IUPHARN/A
BindingDB50184936
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID16570926ChEMBL
Activity27.0 %PMID16570926ChEMBL

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