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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesRattus norvegicus (Rat)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP10980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL309
IUPHAR14
DrugBankN/A

Ligand

Namecarbachol
Molecular formulaC6H15ClN2O2
IUPAC name2-carbamoyloxyethyl(trimethyl)azanium;chloride
Molecular weight182.648
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogPNone
SynonymsKarbachol [Czech]
Carbacol [INN-Spanish]
LS-53194
Carbamoylcholine (chloride)
NCGC00093705-02
[ Show all ]
Inchi KeyAIXAANGOTKPUOY-UHFFFAOYSA-N
Inchi IDInChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
PubChem CID5831
ChEMBLCHEMBL14
IUPHARN/A
BindingDBN/A
DrugBankDB00411

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
ED50<170.0 umol.kg-1PMID7990109ChEMBL
ED5090.0 umol.kg-1PMID7990109ChEMBL
ED50120.0 umol.kg-1PMID7990109ChEMBL
IC5034.0 nMPMID10354408ChEMBL
IC50130.0 nMPMID9622546ChEMBL
IC503100.0 nMPMID9622546ChEMBL
IC5018900.0 nMBioorg. Med. Chem. Lett., (1991) 1:3:147ChEMBL
K app1.9 uMPMID3585909ChEMBL
Ki4.0 nMPMID8246221ChEMBL
Ki20.0 nMPMID9622546ChEMBL
Ki2300.0 nMPMID8246221ChEMBL
Ki5000.0 nMPMID8246221ChEMBL
Ki160000.0 nMPMID8246221ChEMBL
Ratio2.6 -PMID2258905ChEMBL
Ratio1220.0 -PMID8246221ChEMBL

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