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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL237302
Molecular formulaC19H27N7O2
IUPAC name2-amino-N-[(1S)-1-[2-(4-cyanobutyl)tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide
Molecular weight385.472
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP0.7
SynonymsBDBM50222169
(S)-2-amino-N-(2-(benzyloxy)-1-(2-(4-cyanobutyl)-2H-tetrazol-5-yl)ethyl)-2-methylpropanamide
Inchi KeyAIYLRQHXTNYMHM-MRXNPFEDSA-N
Inchi IDInChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-25-26(24-17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1
PubChem CID44434122
ChEMBLCHEMBL237302
IUPHARN/A
BindingDB50222169
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501860.0 nMPMID17869100BindingDB,ChEMBL
Ki<5000.0 nMPMID17869100BindingDB,ChEMBL

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