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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2314312
Molecular formulaC20H19ClN2O3
IUPAC name5-chloro-2-[(3,4-dimethylphenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
Molecular weight370.833
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.2
SynonymsBDBM50425639
SR-02000001061
SR-02000001061-1
Inchi KeyDQWOWXWXWBFQPV-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H19ClN2O3/c1-13-4-5-15(10-14(13)2)12-23-20(24)19(18(21)11-22-23)26-17-8-6-16(25-3)7-9-17/h4-11H,12H2,1-3H3
PubChem CID50904459
ChEMBLCHEMBL2314312
IUPHARN/A
BindingDB50425639
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50610.0 nMPMID23287738BindingDB,ChEMBL

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