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GPCR

NameGastrin/cholecystokinin type B receptor
SpeciesMus musculus (Mouse)
GeneCckbr
SynonymCHOLREC
Cholecystokinin-2 receptor
CCK2-R
CCK2 receptor
CCK-BR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length453
Amino acid sequenceMDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
UniProtP56481
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2854
IUPHAR77
DrugBankN/A

Ligand

NameCHEMBL351310
Molecular formulaC28H30N6O6S2
IUPAC name2-[[4-[2-[2-(1H-indol-3-yl)ethylcarbamothioyl]hydrazinyl]-3-nitrophenyl]sulfonyl-(3-phenylpropyl)amino]acetic acid
Molecular weight610.704
Hydrogen bond acceptor9
Hydrogen bond donor5
XlogP5.4
SynonymsBDBM50097725
N-[3-Nitro-4-[3-[2-(1H-indole-3-yl)ethyl]thioureidoamino]phenylsulfonyl]-N-(3-phenylpropyl)glycine
Inchi KeyDRBUUHDGTWTDTL-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H30N6O6S2/c35-27(36)19-33(16-6-9-20-7-2-1-3-8-20)42(39,40)22-12-13-25(26(17-22)34(37)38)31-32-28(41)29-15-14-21-18-30-24-11-5-4-10-23(21)24/h1-5,7-8,10-13,17-18,30-31H,6,9,14-16,19H2,(H,35,36)(H2,29,32,41)
PubChem CID44375424
ChEMBLCHEMBL351310
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC506000.0 nMPMID11266174ChEMBL

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