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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesMus musculus (Mouse)
GeneHcar2
SynonymProtein PUMA-G
Nicotinic acid receptor
Nic1
Niacr1
niacin receptor 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProtQ9EP66
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4420
IUPHAR312
DrugBankN/A

Ligand

NameCHEMBL482943
Molecular formulaC13H11FN6
IUPAC name5-(4-fluorophenyl)-3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight270.271
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.6
SynonymsSCHEMBL12671514
BDBM50277747
5-(4-fluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Inchi KeyDRPUDPGLWZAJQW-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H11FN6/c14-9-3-1-7(2-4-9)8-5-10-11(6-8)15-16-12(10)13-17-19-20-18-13/h1-4,8H,5-6H2,(H,15,16)(H,17,18,19,20)
PubChem CID12002520
ChEMBLCHEMBL482943
IUPHARN/A
BindingDB50277747
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501700.0 nMPMID19307116BindingDB,ChEMBL

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