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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameSCHEMBL606923
Molecular formulaC27H33N5
IUPAC name4-[(3R)-3-aminopyrrolidin-1-yl]-9,9-dibenzyl-5,6,7,8-tetrahydrocyclohepta[d]pyrimidin-2-amine
Molecular weight427.596
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.1
SynonymsCHEMBL1090741
Inchi KeyDRPYAQVVIVQJET-JOCHJYFZSA-N
Inchi IDInChI=1S/C27H33N5/c28-22-14-16-32(19-22)25-23-13-7-8-15-27(24(23)30-26(29)31-25,17-20-9-3-1-4-10-20)18-21-11-5-2-6-12-21/h1-6,9-12,22H,7-8,13-19,28H2,(H2,29,30,31)/t22-/m1/s1
PubChem CID44466593
ChEMBLCHEMBL1090741
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity129.0 %PMID20171098ChEMBL
pKb4.6 -PMID20171098ChEMBL

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