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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	486
Amino acid sequence	MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P31390
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4701
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL226124
Molecular formula	C34H44F2N4
IUPAC name	1-[1-(4-fluorophenyl)-2-[4-[3-(4-fluoro-2-phenylphenyl)propyl]piperazin-1-yl]ethyl]-4-propan-2-ylpiperazine
Molecular weight	546.751
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	6.4
Synonyms	BDBM50202934 (+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-fluorophenyl)-2-4-isopropylpiperazin-1-yl)ethyl]piperazine
Inchi Key	DRSLEYLXVNRDKA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
PubChem CID	44423455
ChEMBL	CHEMBL226124
IUPHAR	N/A
BindingDB	50202934
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID17234422	BindingDB,ChEMBL

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