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GPCR

NameD(2) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP20288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3998
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL432676
Molecular formulaC10H12FNO2
IUPAC name7-amino-1-fluoro-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight197.209
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP1.1
Synonyms103347-60-0
2,3-Naphthalenediol, 7-amino-1-fluoro-5,6,7,8-tetrahydro-
SCHEMBL10619702
Inchi KeyDTGQQBGSYWRGOX-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H12FNO2/c11-9-7-4-6(12)2-1-5(7)3-8(13)10(9)14/h3,6,13-14H,1-2,4,12H2
PubChem CID13662814
ChEMBLCHEMBL432676
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
K Bind1.27 uMPMID2875183ChEMBL

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