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Name | Substance-P receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | TACR1 |
Synonym | NK-1 receptor NK-1R SPR Tachykinin receptor 1 |
Disease | N/A for non-human GPCRs |
Length | 407 |
Amino acid sequence | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS |
UniProt | P30547 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3942 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CP-99994 |
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Molecular formula | C19H24N2O |
IUPAC name | (2S,3S)-N-[(2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine |
Molecular weight | 296.414 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | Tritiated-(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine (+/-)(2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-amine (2S,3S)-3-(2-methoxybenzyl)amino-2-phenylpiperdine CP 99994 D05ETM [ Show all ] |
Inchi Key | DTQNEFOKTXXQKV-HKUYNNGSSA-N |
Inchi ID | InChI=1S/C19H24N2O/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3/t17-,19-/m0/s1 |
PubChem CID | 5311057 |
ChEMBL | CHEMBL441225 |
IUPHAR | 2102 |
BindingDB | 50000041 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2.9 nM | PMID11266174 | BindingDB,ChEMBL |
Kd | 0.32 nM | PMID7693945 | BindingDB |
Ki | 0.17 nM | PMID7693945 | ChEMBL |
Ki | 0.27 nM | PMID7693945 | ChEMBL |
Ki | 0.27 nM | PMID7693945 | BindingDB |
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