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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	FAUC 213
Molecular formula	C18H19ClN4
IUPAC name	2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.2
Synonyms	2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-pyrazolo[1,5-a]pyridine DTXSID40187460 J-019326 Tox21_501144 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine CCG-222448 FAUC-213 NCGC00165795-01 4-(4-Chloro-phenyl)-1-pyrazolo[1,5-a]pyridin-2-ylmethyl-piperazin-1-ium CTK8E8281 GTPL974 Pyrazolo(1,5-a)pyridine, 2-((4-(4-chlorophenyl)-1-piperazinyl)methyl)- 2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine API0002679 LP01144 UNII-G8F040299R 2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine FAUC213 NCGC00165795-02 D09WBJ HMS3263F09 RT-012699 2-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine BDBM50102712 FAUC 213, >=98% (HPLC), solid MFCD06798338 ZINC52541476 337972-47-1 CHEMBL310843 G8F040299R NCGC00261829-01 [ Show all ]
Inchi Key	DTRXURJDKOYCCD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
PubChem CID	10336538
ChEMBL	CHEMBL310843
IUPHAR	974
BindingDB	50102712
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	46.0 nM	PMID19606869	ChEMBL
Ki	76.0 nM	PMID19606869	ChEMBL
Ki	730.0 nM	PMID19606869	ChEMBL
Ki	1600.0 nM	PMID19606869	ChEMBL
Ki	2500.0 nM	PMID19606869	ChEMBL
Ki	5000.0 nM	PMID23920439	ChEMBL
Ki	5248.07 nM	PMID17266201	ChEMBL
Ki	5300.0 nM	PMID19606869, PMID18307287, PMID18164618, PMID11495580, PMID15689154	BindingDB,ChEMBL
Ki	8300.0 nM	PMID19606869	BindingDB,ChEMBL
Ki	9200.0 nM	PMID19606869	ChEMBL
Ki	12000.0 nM	PMID19606869	ChEMBL

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