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GPCR

NameG-protein coupled receptor homolog US28
SpeciesHuman cytomegalovirus (strain AD169) (HHV-5)
GeneUS28
SynonymHHRF3
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProtP69332
Protein Data Bank4xt1
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4xt1.
BioLiPBL0309402,BL0309403
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4259
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL198111
Molecular formulaC28H32ClNO2
IUPAC name4-(4-chlorophenyl)-1-[4-(4-methoxyphenyl)-4-phenylbutyl]piperidin-4-ol
Molecular weight450.019
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP6.1
SynonymsBDBM50027220
4-(4-Chloro-phenyl)-1-[4-(4-methoxy-phenyl)-4-phenyl-butyl]-piperidin-4-ol
Inchi KeyDTTPNSUBWNUHRU-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H32ClNO2/c1-32-26-15-9-23(10-16-26)27(22-6-3-2-4-7-22)8-5-19-30-20-17-28(31,18-21-30)24-11-13-25(29)14-12-24/h2-4,6-7,9-16,27,31H,5,8,17-21H2,1H3
PubChem CID11705066
ChEMBLCHEMBL198111
IUPHARN/A
BindingDB50027220
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5015500.0 nMPMID16190772BindingDB,ChEMBL

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