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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641729
Molecular formulaC15H16F2N4O2
IUPAC name5-(difluoromethoxy)-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight322.316
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP2.0
Synonyms(R)-5-(difluoromethoxy)-N-(4-(morpholin-2-yl)phenyl)pyrimidin-2-amine
BDBM129537
DUCFIFULTZWOSS-ZDUSSCGKSA-N
SCHEMBL12609698
US8802673, 179
Inchi KeyDUCFIFULTZWOSS-ZDUSSCGKSA-N
Inchi IDInChI=1S/C15H16F2N4O2/c16-14(17)23-12-7-19-15(20-8-12)21-11-3-1-10(2-4-11)13-9-18-5-6-22-13/h1-4,7-8,13-14,18H,5-6,9H2,(H,19,20,21)/t13-/m0/s1
PubChem CID68325483
ChEMBLCHEMBL3641729
IUPHARN/A
BindingDB129537
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki51.7 nM, NoneBindingDB,ChEMBL

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