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GPCR

NameAdenosine receptor A3
SpeciesRattus norvegicus (Rat)
GeneAdora3
SynonymARA3
Adenosine receptor A3
A3 receptor
TGPCR1
A3AR
DiseaseN/A for non-human GPCRs
Length320
Amino acid sequenceMKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
UniProtP28647
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3360
IUPHAR21
DrugBankN/A

Ligand

NameAC1LA9RB
Molecular formulaC11H13ClN4O3
IUPAC name(2R,3S,5R)-5-(7-amino-5-chloroimidazo[4,5-b]pyridin-3-yl)-2-(hydroxymethyl)oxolan-3-ol
Molecular weight284.7
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP1.1
Synonyms(2R,3S,5R)-5-(7-amino-5-chloro-imidazo[4,5-b]pyridin-3-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
(2R,3S,5R)-5-(7-amino-5-chloroimidazo[4,5-b]pyridin-3-yl)-2-(hydroxymethyl)oxolan-3-ol
2-Chloro-2'-deoxy-1-deazaadenosine
2Cl-1-Deaza-2'-dA
3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-chloro-3H-imidazo[4,5-b]pyridine-7-amine
[ Show all ]
Inchi KeyDUCXWDWEQQGOTG-LKEWCRSYSA-N
Inchi IDInChI=1S/C11H13ClN4O3/c12-8-1-5(13)10-11(15-8)16(4-14-10)9-2-6(18)7(3-17)19-9/h1,4,6-7,9,17-18H,2-3H2,(H2,13,15)/t6-,7+,9+/m0/s1
PubChem CID464418
ChEMBLCHEMBL3142967
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Displacement21.0 %PMID7707320ChEMBL

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