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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL2036824
Molecular formulaC13H10N2O4S
IUPAC name5-(2-thiophen-2-ylethyl)-1H-pyrano[2,3-d]pyrimidine-2,4,7-trione
Molecular weight290.293
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP0.7
SynonymsSCHEMBL12602874
BDBM50384646
Inchi KeyAJGQQTCONOGWIG-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H10N2O4S/c16-9-6-7(3-4-8-2-1-5-20-8)10-11(17)14-13(18)15-12(10)19-9/h1-2,5-6H,3-4H2,(H2,14,15,17,18)
PubChem CID59304594
ChEMBLCHEMBL2036824
IUPHARN/A
BindingDB50384646
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5047.0 nMPMID24900372BindingDB,ChEMBL

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