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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
serotonin 1c receptor
HTR1C
5-hydroxytryptamine receptor 1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Ligand

NameCHEMBL138989
Molecular formulaC21H25N3O
IUPAC name[(2R,4R)-2,4-dimethylazetidin-1-yl]-[(9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]methanone
Molecular weight335.451
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP3.2
SynonymsBDBM50118577
PDSP1_001227
PDSP2_001210
Inchi KeyDUKNIHFTDAXJON-RCZCSUKSSA-N
Inchi IDInChI=1S/C21H25N3O/c1-12-7-13(2)24(12)21(25)15-8-17-16-5-4-6-18-20(16)14(10-22-18)9-19(17)23(3)11-15/h4-6,8,10,12-13,15,19,22H,7,9,11H2,1-3H3/t12-,13-,15-,19?/m1/s1
PubChem CID11121216
ChEMBLCHEMBL138989
IUPHARN/A
BindingDB50118577
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki130.0 nMPMID12213075BindingDB,ChEMBL

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