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GPCR

NameVasopressin V2 receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr2
SynonymAVPR V2
Antidiuretic hormone receptor
ADHR
Renal-type arginine vasopressin receptor
V2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length371
Amino acid sequenceMLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProtQ00788
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3766
IUPHAR368
DrugBankN/A

Ligand

NameCHEMBL264513
Molecular formulaC54H79N15O12S2
IUPAC name(2S)-N-[(2S)-1-[[2-(2-aminoethylamino)-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10S,13R,16S,19R,22S)-13-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-hydroxyphenyl)methyl]-23-methyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]pyrrolidine-2-carboxamide
Molecular weight1194.44
Hydrogen bond acceptor16
Hydrogen bond donor13
XlogP-2.7
SynonymsN/A
Inchi KeyDUPKOTLWRHAZMR-QUMOEEMLSA-N
Inchi IDInChI=1S/C54H79N15O12S2/c1-68-41(27-33-14-16-34(70)17-15-33)51(80)66-37(26-32-10-4-2-5-11-32)48(77)63-36(18-19-42(56)71)47(76)65-38(28-43(57)72)49(78)67-39(31-82-83-54(29-45(68)74)20-6-3-7-21-54)52(81)69-25-9-13-40(69)50(79)64-35(12-8-23-61-53(58)59)46(75)62-30-44(73)60-24-22-55/h2,4-5,10-11,14-17,35-41,70H,3,6-9,12-13,18-31,55H2,1H3,(H2,56,71)(H2,57,72)(H,60,73)(H,62,75)(H,63,77)(H,64,79)(H,65,76)(H,66,80)(H,67,78)(H4,58,59,61)/t35-,36-,37+,38+,39+,40-,41-/m0/s1
PubChem CID44350575
ChEMBLCHEMBL264513
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Effective dose16.0 nM kg-1PMID1531076ChEMBL
Kd6.6 nMPMID1531076ChEMBL

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