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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL1672746
Molecular formulaC11H11FN2O3
IUPAC name5-ethyl-2-(1-fluoroethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Molecular weight238.218
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP0.6
SynonymsBDBM50337015
5-ethyl-2-(1-fluoroethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Inchi KeyAJKUHQWTPIKCLG-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H11FN2O3/c1-3-6-4-7(15)17-11-8(6)10(16)13-9(14-11)5(2)12/h4-5H,3H2,1-2H3,(H,13,14,16)
PubChem CID53318740
ChEMBLCHEMBL1672746
IUPHARN/A
BindingDB50337015
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC506065.0 nMPMID24900295BindingDB,ChEMBL

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