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GPCR

NameMu-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRM1
SynonymhMOP
M-OR-1
MOP
opioid receptor, mu 1
opioid receptor
[ Show all ]
DiseaseDiarrhea
Inflammatory disease
Pain
Major depressive disorder
Migraine
[ Show all ]
Length400
Amino acid sequenceMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtP35372
Protein Data BankN/A
GPCR-HGmod modelP35372
3D structure modelThis predicted structure model is from GPCR-EXP P35372.
BioLiPN/A
Therapeutic Target DatabaseT47768
ChEMBLCHEMBL233
IUPHAR319
DrugBankBE0000770

Ligand

NameCHEMBL2322511
Molecular formulaC34H40N4O3
IUPAC nameN-[3-[[3-[1-(cyclopropylmethyl)piperidin-4-yl]oxybenzoyl]amino]phenyl]-3-piperidin-1-ylbenzamide
Molecular weight552.719
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.9
SynonymsBDBM50427044
Inchi KeyAJLLHPKYDCMVMR-UHFFFAOYSA-N
Inchi IDInChI=1S/C34H40N4O3/c39-33(26-7-4-11-30(21-26)38-17-2-1-3-18-38)35-28-9-6-10-29(23-28)36-34(40)27-8-5-12-32(22-27)41-31-15-19-37(20-16-31)24-25-13-14-25/h4-12,21-23,25,31H,1-3,13-20,24H2,(H,35,39)(H,36,40)
PubChem CID71716193
ChEMBLCHEMBL2322511
IUPHARN/A
BindingDB50427044
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<30000.0 nMPMID23360448BindingDB,ChEMBL

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