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GPCR

NameProbable G-protein coupled receptor 142
SpeciesHomo sapiens (Human)
GeneGPR142
SynonymKIF19
G-protein coupled receptor PGR2
GPR142
AXOR103
DiseaseN/A
Length462
Amino acid sequenceMSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProtQ7Z601
Protein Data BankN/A
GPCR-HGmod modelQ7Z601
3D structure modelThis predicted structure model is from GPCR-EXP Q7Z601.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069161
IUPHAR132
DrugBankN/A

Ligand

NameCHEMBL2164841
Molecular formulaC26H25N5O2
IUPAC name(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(2-pyridin-2-ylethylamino)propanamide
Molecular weight439.519
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP2.2
SynonymsBDBM50395793
Inchi KeyDWRDAUZMBBZNJN-QHCPKHFHSA-N
Inchi IDInChI=1S/C26H25N5O2/c32-25-24(17-21(18-30-25)20-9-13-27-14-10-20)31-26(33)23(16-19-6-2-1-3-7-19)29-15-11-22-8-4-5-12-28-22/h1-10,12-14,17-18,23,29H,11,15-16H2,(H,30,32)(H,31,33)/t23-/m0/s1
PubChem CID71449754
ChEMBLCHEMBL2164841
IUPHARN/A
BindingDB50395793
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501320.0 nMPMID22926069BindingDB,ChEMBL
Emax76.0 %PMID22926069ChEMBL

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