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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameSR-02000000351
Molecular formulaC18H12ClF3N2O2
IUPAC name5-chloro-2-(4-methylphenyl)-4-[4-(trifluoromethyl)phenoxy]pyridazin-3-one
Molecular weight380.751
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP4.9
SynonymsSR-02000000351-1
CHEMBL1698879
BDBM75883
cid_46172942
SR-02000000351-2
[ Show all ]
Inchi KeyDWXDDJWWZYYTMI-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H12ClF3N2O2/c1-11-2-6-13(7-3-11)24-17(25)16(15(19)10-23-24)26-14-8-4-12(5-9-14)18(20,21)22/h2-10H,1H3
PubChem CID46172942
ChEMBLCHEMBL1698879
IUPHARN/A
BindingDB75883
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50880.0 nMPMID23079522BindingDB,ChEMBL
IC502200.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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