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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | CHEMBL2113386 |
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Molecular formula | C20H22IN3O2S |
IUPAC name | 1-(2-iodophenyl)-N-[3-[[(2R)-pyrrolidin-2-yl]methyl]-1H-indol-5-yl]methanesulfonamide |
Molecular weight | 495.379 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 3.5 |
Synonyms | N/A |
Inchi Key | DXNOFPQQCQAJFH-MRXNPFEDSA-N |
Inchi ID | InChI=1S/C20H22IN3O2S/c21-19-6-2-1-4-14(19)13-27(25,26)24-17-7-8-20-18(11-17)15(12-23-20)10-16-5-3-9-22-16/h1-2,4,6-8,11-12,16,22-24H,3,5,9-10,13H2/t16-/m1/s1 |
PubChem CID | 71459954 |
ChEMBL | CHEMBL2113386 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.4 nM | PMID19758807, PMID15658848 | ChEMBL |
Emax | 100.0 % | PMID15658848 | ChEMBL |
Ki | 1.0 nM | PMID19758807, PMID15658848 | ChEMBL |
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