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Name | Free fatty acid receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | carboxylic acid agonist, 27 |
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Molecular formula | C16H16BrNO2 |
IUPAC name | 3-[4-[(3-bromophenyl)methylamino]phenyl]propanoic acid |
Molecular weight | 334.213 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 3.8 |
Synonyms | CHEMBL394666 3-(4-{[(3-bromophenyl)methyl]amino}phenyl)propanoic acid BDBM22510 |
Inchi Key | DYTMZTWHJZNJMP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H16BrNO2/c17-14-3-1-2-13(10-14)11-18-15-7-4-12(5-8-15)6-9-16(19)20/h1-5,7-8,10,18H,6,9,11H2,(H,19,20) |
PubChem CID | 24825492 |
ChEMBL | CHEMBL394666 |
IUPHAR | N/A |
BindingDB | 22510 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 120.0 % | PMID17240142 | ChEMBL |
EC50 | 173.78 nM | PMID24900217 | ChEMBL |
EC50 | 239.88 nM | PMID22519963 | BindingDB,ChEMBL |
EC50 | 794.0 nM | PMID17240142 | BindingDB |
EC50 | 794.33 nM | PMID17240142 | ChEMBL |
Efficacy | 87.0 % | PMID22519963 | ChEMBL |
Efficacy | 110.0 % | PMID24900217 | ChEMBL |
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