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GPCR

NameD(3) dopamine receptor
SpeciesChlorocebus aethiops (Green monkey)
GeneDRD3
SynonymDopamine D3 receptor
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProtP52703
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2304406
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL356542
Molecular formulaC24H26N4O
IUPAC name1-phenyl-8-[(1-phenylpyrrol-3-yl)methyl]-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight386.499
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.5
SynonymsBDBM50048239
1-Phenyl-8-(1-phenyl-1H-pyrrol-3-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
Inchi KeyDZHKYKKLIHHVIU-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H26N4O/c29-23-24(28(19-25-23)22-9-5-2-6-10-22)12-15-26(16-13-24)17-20-11-14-27(18-20)21-7-3-1-4-8-21/h1-11,14,18H,12-13,15-17,19H2,(H,25,29)
PubChem CID10572229
ChEMBLCHEMBL356542
IUPHARN/A
BindingDB50048239
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki90.0 nMPMID8523409BindingDB,ChEMBL

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