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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL572588 |
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Molecular formula | C16H19ClF2N4O3 |
IUPAC name | 5-chloro-3-[[6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl]amino]-1-[(2R)-1-methoxypropan-2-yl]pyrazin-2-one |
Molecular weight | 388.8 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | BDBM50300143 (R)-5-Chloro-3-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-1-(2-methoxy-1-methylethyl)pyrazin-2(1H)-one |
Inchi Key | DZTDHMGXIRVSAW-SECBINFHSA-N |
Inchi ID | InChI=1S/C16H19ClF2N4O3/c1-8-5-11(10(3)20-14(8)26-16(18)19)21-13-15(24)23(6-12(17)22-13)9(2)7-25-4/h5-6,9,16H,7H2,1-4H3,(H,21,22)/t9-/m1/s1 |
PubChem CID | 44596587 |
ChEMBL | CHEMBL572588 |
IUPHAR | N/A |
BindingDB | 50300143 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 1.6 nM | PMID19954247 | BindingDB,ChEMBL |
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