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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	FASDKYOPVNHBLU-UHFFFAOYSA-N
Molecular formula	C10H17N3S
IUPAC name	6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Molecular weight	211.327
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.9
Synonyms	BEN629 I09-0213 N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (+/-)2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine CHEMBL76399 MolPort-006-395-737 T5932 104617-86-9 AC1Q4W5N AN-5403 HMS3393A21 N6-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine (Pramipexole, PPX) (+/-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Benzene,4-chloro-1-(trifluoromethoxy)-2-(trifluoromethyl)- L000492 N~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride (S)-2-Amnio-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole A801038 AKOS017258887 N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine TRA0068140 (+/-) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl- BDBM50017550 HMS3657G15 N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine (+/-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole MCULE-4233228077 SCHEMBL195775 AC1L1J65 ALBB-027263 HMS3370D06 N6-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine VZ30192 (+/-)-2-amino-6-(N-propylamino)-4,5,6,7-tetrahydrobenzothiazole 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-N~6~-propyl-, dihydrochloride [ Show all ]
Inchi Key	FASDKYOPVNHBLU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
PubChem CID	4885
ChEMBL	CHEMBL76399
IUPHAR	N/A
BindingDB	50017550
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12388666	PDSP,BindingDB
Ki	52.2 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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