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GPCR

NameBombesin receptor subtype-3
SpeciesHomo sapiens (Human)
GeneBRS3
Synonymbb3
BRS-3
bombesin receptor subtype-3
BB3 receptor
bombesin like receptor 3
DiseaseBreast cancer
Cancer
Length399
Amino acid sequenceMAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
UniProtP32247
Protein Data BankN/A
GPCR-HGmod modelP32247
3D structure modelThis predicted structure model is from GPCR-EXP P32247.
BioLiPN/A
Therapeutic Target DatabaseT68887
ChEMBLCHEMBL4080
IUPHAR40
DrugBankN/A

Ligand

NameCHEMBL1204083
Molecular formulaC14H21ClN6
IUPAC name5-piperidin-1-yl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c][2,7]naphthyridin-1-amine;hydrochloride
Molecular weight308.814
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogPNone
SynonymsN/A
Inchi KeyFBJBOPYFCQOHQL-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H20N6.ClH/c15-12-11-9-4-5-16-8-10(9)14(17-13(11)19-18-12)20-6-2-1-3-7-20;/h16H,1-8H2,(H3,15,17,18,19);1H
PubChem CID49861361
ChEMBLCHEMBL1204083
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.3 %PMID20371178ChEMBL
EC50<10000.0 nMPMID20371178ChEMBL

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