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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701929
Molecular formulaC17H18Cl2N2O
IUPAC nameN-[(3,4-dichlorophenyl)methyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight337.244
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.7
SynonymsSCHEMBL12610157
BDBM129388
US8802673, 30
Inchi KeyFBQKSMQDCGXVFK-QGZVFWFLSA-N
Inchi IDInChI=1S/C17H18Cl2N2O/c18-15-6-1-12(9-16(15)19)10-21-14-4-2-13(3-5-14)17-11-20-7-8-22-17/h1-6,9,17,20-21H,7-8,10-11H2/t17-/m1/s1
PubChem CID68325808
ChEMBLCHEMBL3701929
IUPHARN/A
BindingDB129388
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki41.7 nM, NoneBindingDB,ChEMBL

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