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GPCR

NameEndothelin receptor type B
SpeciesRattus norvegicus (Rat)
GeneEdnrb
SynonymHSCR
ETB receptor
ET-BR
ET-B
Endothelin receptor non-selective type
[ Show all ]
DiseaseN/A for non-human GPCRs
Length442
Amino acid sequenceMQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP21451
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4631
IUPHAR220
DrugBankN/A

Ligand

NameCHEMBL35527
Molecular formulaC28H21ClKNO9
IUPAC namepotassium;3-[[2-(carboxymethoxy)-4-methoxyphenyl]methyl]-1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-4-oxoquinoline-2-carboxylate
Molecular weight590.022
Hydrogen bond acceptor10
Hydrogen bond donor1
XlogPNone
SynonymsN/A
Inchi KeyFCAHQTXEKQTSAO-UHFFFAOYSA-M
Inchi IDInChI=1S/C28H22ClNO9.K/c1-36-17-7-6-15(22(10-17)37-13-25(31)32)8-19-26(28(34)35)30(21-5-3-2-4-18(21)27(19)33)12-16-9-23-24(11-20(16)29)39-14-38-23;/h2-7,9-11H,8,12-14H2,1H3,(H,31,32)(H,34,35);/q;+1/p-1
PubChem CID44283667
ChEMBLCHEMBL35527
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Binding affinity549.0 nMPMID10888339ChEMBL

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