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GPCR

NameVasopressin V1a receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr1a
SynonymAVPR
AVPR V1a
AVPR1
antidiuretic hormone receptor 1a
V1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length424
Amino acid sequenceMSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
UniProtP30560
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2868
IUPHAR366
DrugBankN/A

Ligand

NameCHEMBL416505
Molecular formulaC20H21N3O2
IUPAC name1-[1-(pyridine-4-carbonyl)piperidin-4-yl]-3,4-dihydroquinolin-2-one
Molecular weight335.407
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP1.9
SynonymsBDBM50045169
1-[1-(Pyridine-4-carbonyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one
1-[1-(4-Pyridinylcarbonyl)-4-piperidinyl]-3,4-dihydro-2(1H)-quinolone
Inchi KeyFCFIXKIPVHSFDC-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H21N3O2/c24-19-6-5-15-3-1-2-4-18(15)23(19)17-9-13-22(14-10-17)20(25)16-7-11-21-12-8-16/h1-4,7-8,11-12,17H,5-6,9-10,13-14H2
PubChem CID14969507
ChEMBLCHEMBL416505
IUPHARN/A
BindingDB50045169
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5037000.0 nMPMID8393113BindingDB,ChEMBL

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