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Name | Beta-3 adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adrb3 |
Synonym | beta3-adrenoceptor beta3-adrenergic receptor Beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 400 |
Amino acid sequence | MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT |
UniProt | P26255 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4031 |
IUPHAR | 30 |
DrugBank | N/A |
Name | CHEMBL436166 |
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Molecular formula | C36H44ClNO11 |
IUPAC name | bis(cyclohexanecarbonyloxymethyl) 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate |
Molecular weight | 702.194 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 2 |
XlogP | 7.5 |
Synonyms | 5-[(R)-2-[[(R)-beta-Hydroxy-3-chlorophenethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid bis(cyclohexylcarbonyloxymethyl) ester |
Inchi Key | FCXDFNJJQNWOHQ-BTYSJIOQSA-N |
Inchi ID | InChI=1S/C36H44ClNO11/c1-23(38-20-29(39)27-13-8-14-28(37)19-27)17-24-15-16-30-31(18-24)49-36(48-30,34(42)46-21-44-32(40)25-9-4-2-5-10-25)35(43)47-22-45-33(41)26-11-6-3-7-12-26/h8,13-16,18-19,23,25-26,29,38-39H,2-7,9-12,17,20-22H2,1H3/t23-,29+/m1/s1 |
PubChem CID | 44300281 |
ChEMBL | CHEMBL436166 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Response | 19.0 % | PMID10450954 | ChEMBL |
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