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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesMus musculus (Mouse)
GeneHcar2
SynonymProtein PUMA-G
Nicotinic acid receptor
Nic1
Niacr1
niacin receptor 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProtQ9EP66
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4420
IUPHAR312
DrugBankN/A

Ligand

Name5932-32-1
Molecular formulaC7H8N2O2
IUPAC name1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid
Molecular weight152.153
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP0.8
Synonyms1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid
1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid
884497-47-6
1H,4H,5H,6H-Cyclopenta[C]Pyrazole-3-Carboxylic Acid
3-cyclopentapyrazolecarboxylic acid, 1,4,5,6-tetrahydro-
[ Show all ]
Inchi KeyFCYBBDFUBSEGMX-UHFFFAOYSA-N
Inchi IDInChI=1S/C7H8N2O2/c10-7(11)6-4-2-1-3-5(4)8-9-6/h1-3H2,(H,8,9)(H,10,11)
PubChem CID776416
ChEMBLCHEMBL128604
IUPHARN/A
BindingDB50132140
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50500.0 nMPMID18665582BindingDB,ChEMBL
Efficacy97.0 %PMID18665582ChEMBL

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