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GPCR

NameMelanocortin receptor 4
SpeciesHomo sapiens (Human)
GeneMC4R
SynonymMC4-R
MC4 receptor
DiseaseObesity; Sexual dysfunction
Obesity; Diabetes
Obesity
Metabolic disorders
Sexual dysfunction
[ Show all ]
Length332
Amino acid sequenceMVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProtP32245
Protein Data BankN/A
GPCR-HGmod modelP32245
3D structure modelThis predicted structure model is from GPCR-EXP P32245.
BioLiPN/A
Therapeutic Target DatabaseT72458
ChEMBLCHEMBL259
IUPHAR285
DrugBankN/A

Ligand

NameMLS003124195
Molecular formulaC23H21FN4O
IUPAC nameN-[6-[4-(dimethylamino)phenyl]-3-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]acetamide
Molecular weight388.446
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.5
SynonymsCHEMBL1873621
SMR001292866
Inchi KeyAKHKMYWFQIREIE-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H21FN4O/c1-15(29)26-21-12-18(16-6-10-20(11-7-16)27(2)3)14-28-22(13-25-23(21)28)17-4-8-19(24)9-5-17/h4-14H,1-3H3,(H,26,29)
PubChem CID49795091
ChEMBLCHEMBL1873621
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<9912.0 nMPubChem BioAssay data setChEMBL

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