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GPCR

NameD(1A) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtQ95136
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2967
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL131120
Molecular formulaC14H22N4
IUPAC nameN-[2-(2H-benzotriazol-5-yl)ethyl]-N-propylpropan-1-amine
Molecular weight246.358
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
SynonymsBDBM50279972
N,N-Dipropyl-1H-benzotriazole-5-(ethanamine)
[2-(3H-Benzotriazol-5-yl)-ethyl]-dipropyl-amine
Inchi KeyFDQPYJACWKLJIS-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H22N4/c1-3-8-18(9-4-2)10-7-12-5-6-13-14(11-12)16-17-15-13/h5-6,11H,3-4,7-10H2,1-2H3,(H,15,16,17)
PubChem CID10399692
ChEMBLCHEMBL131120
IUPHARN/A
BindingDB50279972
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<100000.0 nM, Bioorg. Med. Chem. Lett., (1991) 1:8:403BindingDB,ChEMBL

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