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GPCR

NameGonadotropin-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGnrhr
Synonymluteinizing hormone-releasing hormone (LHRH) receptor
luliberin receptor
LHRHR
LHRH receptor
GNRHR1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length327
Amino acid sequenceMANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProtP30969
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3066
IUPHAR256
DrugBankN/A

Ligand

NameCHEMBL3278580
Molecular formulaC48H77N13O12
IUPAC name(2S)-N-[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight1028.22
Hydrogen bond acceptor13
Hydrogen bond donor13
XlogP-0.7
SynonymsN/A
Inchi KeyAKKFSKOBWJUSQH-QNHAFJONSA-N
Inchi IDInChI=1S/C48H77N13O12/c1-8-26(5)38(60-41(67)31-18-19-37(64)55-31)46(72)54-28(7)40(66)59-35(24-62)44(70)58-34(23-29-14-16-30(63)17-15-29)42(68)53-27(6)39(65)57-33(22-25(3)4)43(69)56-32(12-10-20-52-48(49)50)47(73)61-21-11-13-36(61)45(71)51-9-2/h14-17,25-28,31-36,38,62-63H,8-13,18-24H2,1-7H3,(H,51,71)(H,53,68)(H,54,72)(H,55,64)(H,56,69)(H,57,65)(H,58,70)(H,59,66)(H,60,67)(H4,49,50,52)/t26-,27+,28-,31-,32-,33-,34-,35-,36-,38-/m0/s1
PubChem CID90680317
ChEMBLCHEMBL3278580
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity42.0 ng/mlPMID327068ChEMBL
Activity49.0 ng/mlPMID327068ChEMBL
Activity1017.0 ng/mlPMID327068ChEMBL
Activity1909.0 ng/mlPMID327068ChEMBL

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