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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesCavia porcellus (Guinea pig)
GeneHTR4
Synonym5-HT-4
5-HT4
Serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceMDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProtO70528
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5017
IUPHARN/A
DrugBankN/A

Ligand

Name(R)-zacopride
Molecular formulaC15H20ClN3O2
IUPAC name4-amino-N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2-methoxybenzamide
Molecular weight309.794
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.7
Synonyms4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide
GTPL2288
ZACOPRIDE,S
r-zacopride
38126EQF7A
[ Show all ]
Inchi KeyFEROPKNOYKURCJ-ZDUSSCGKSA-N
Inchi IDInChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
PubChem CID9819593
ChEMBLCHEMBL27846
IUPHARN/A
BindingDB50031475
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity84.0 %PMID9046352ChEMBL
EC50166.0 nMPMID9046352BindingDB,ChEMBL
Intrinsic activity1.9 -PMID7608898ChEMBL
Ki199.52 nMPMID7984267BindingDB
Ki251.18 nMPMID7984267BindingDB
Ki2818.0 nMN/ABindingDB
Ki2818.38 nMBioorg. Med. Chem. Lett., (1996) 6:4:477ChEMBL
pD26.8 -PMID7608898ChEMBL

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