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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTRAR1
TA1 receptor
TAR1
trace amine receptor 1
TaR-1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3701958
Molecular formulaC16H16ClFN2O
IUPAC name4-chloro-2-fluoro-N-[4-[(2S)-morpholin-2-yl]phenyl]aniline
Molecular weight306.765
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.2
SynonymsSCHEMBL12609714
BDBM129417
US8802673, 59
Inchi KeyFESASGWFZWHHCS-MRXNPFEDSA-N
Inchi IDInChI=1S/C16H16ClFN2O/c17-12-3-6-15(14(18)9-12)20-13-4-1-11(2-5-13)16-10-19-7-8-21-16/h1-6,9,16,19-20H,7-8,10H2/t16-/m1/s1
PubChem CID68325498
ChEMBLCHEMBL3701958
IUPHARN/A
BindingDB129417
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4.9 nM, NoneBindingDB,ChEMBL

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