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GPCR

NameAdenosine receptor A3
SpeciesRattus norvegicus (Rat)
GeneAdora3
SynonymARA3
Adenosine receptor A3
A3 receptor
TGPCR1
A3AR
DiseaseN/A for non-human GPCRs
Length320
Amino acid sequenceMKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
UniProtP28647
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3360
IUPHAR21
DrugBankN/A

Ligand

Name8-Cyclopentyl-1,3-dipropylxanthine
Molecular formulaC16H24N4O2
IUPAC name8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione
Molecular weight304.394
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.0
SynonymsDPCPX
102146-07-6
8-cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
1,3-Dpcpx
1,3-dipropyl-8-cyclopentylxanthine
[ Show all ]
Inchi KeyFFBDFADSZUINTG-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
PubChem CID1329
ChEMBLCHEMBL183
IUPHAR386
BindingDB21173
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki25.1189 - 42658.0 nMPMID7929142, PMID16902942, PMID9351976IUPHAR
Ki5290.0 nMPMID7932565BindingDB,ChEMBL

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