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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL561225 |
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Molecular formula | C18H17F3N4O2 |
IUPAC name | 1-[(1R)-1-cyclopropylethyl]-5-ethynyl-3-[[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]amino]pyrazin-2-one |
Molecular weight | 378.355 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 2.4 |
Synonyms | BDBM50293989 (R)-1-(1-Cyclopropylethyl)-5-ethynyl-3-[6-methoxy-2-(trifluoromethyl)pyridin-3-ylamino]pyrazin-2(1H)-one |
Inchi Key | FFUTZEOOGWFPMZ-SNVBAGLBSA-N |
Inchi ID | InChI=1S/C18H17F3N4O2/c1-4-12-9-25(10(2)11-5-6-11)17(26)16(22-12)23-13-7-8-14(27-3)24-15(13)18(19,20)21/h1,7-11H,5-6H2,2-3H3,(H,22,23)/t10-/m1/s1 |
PubChem CID | 44190559 |
ChEMBL | CHEMBL561225 |
IUPHAR | N/A |
BindingDB | 50293989 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 5.6 nM | PMID19552437 | BindingDB,ChEMBL |
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