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GPCR

NameD(2) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP20288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3998
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL99291
Molecular formulaC15H26N2O
IUPAC name[(7R)-7-(dipropylamino)-5,6,7,8-tetrahydroindolizin-3-yl]methanol
Molecular weight250.386
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP2.1
SynonymsBDBM50105725
((R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-3-yl)-methanol
Inchi KeyFFZALGRQJRVCKO-CYBMUJFWSA-N
Inchi IDInChI=1S/C15H26N2O/c1-3-8-16(9-4-2)13-7-10-17-14(11-13)5-6-15(17)12-18/h5-6,13,18H,3-4,7-12H2,1-2H3/t13-/m1/s1
PubChem CID44329299
ChEMBLCHEMBL99291
IUPHARN/A
BindingDB50105725
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4700.0 nMPMID11597417BindingDB,ChEMBL
Ki37000.0 nMPMID11597417BindingDB,ChEMBL

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